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KMID : 0613820100200101511
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Journal of Life Science
2010 Volume.20 No. 10 p.1511 ~ p.1518
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Isolation and Identification of Inhibitory Compounds on Helicobacter pylori from Rosa multiflora Thunberg Fruit Extracts
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Park Ki-Tae
Kim Jin-Sung
Jo Bun-Sung
An Bong-Jeun
Chun Sung-Sook
Kim Jeung-Hoan
Cho Young-Je
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Abstract
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The antimicrobial activity of 70% ethanol extracts from Rosa multiflora Thunberg fruit against Helicobacter pylori was examined. The inhibitory activity of Rosa multiflora Thunberg fruit extracts against H. pylori was determined to clear a zone of 14 mm with 70% ethanol extracts. Purification of inhibitory compounds was carried on Sephadex LH-20 and C₁? cartridge column chromatography using a gradient procedure, with increasing ethanol (0→100%) in H₂O. The chemical structure of the purified inhibitory compounds on H. pylori was identified to be protocatechuic acid, chlorogenic acid and quercetin by FAB-MS, NMR and IR spectrum.
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KEYWORD
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Helicobacter pylori, Rosa multiflora Thunberg fruit, isolation, identification, inhibitory compounds
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